Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease.
Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis.
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s disease.
Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases.
