LoQus23 researchers awarded grant to understand if repeat instability is therapeutically relevant in Friedriech’s ataxia

Dr Caroline Benn (CSO ​of LoQus23) and Dr Ricardo Mouro Pinto (Massachusetts General Hospital) are co-recipients of a Friedreich’s Ataxia Research Alliance grant (supported by the Crisp Family Fund). Like Huntington’s disease, Friedreich’s ataxia ​(FA) is a trinucleotide repeat expansion disease that has somatic instability – but understanding of how this instability contributes to disease progression is currently limited. The research funded by the grant will use disease models to study this in more detail in the Mouro Pinto lab, ​and determine if targeting aberrant DNA Mismatch Repair pathways can help treat FA.